The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases

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The synthesis of peptidylfluoromethanes and their properties as inhibitors of serine proteinases and cysteine proteinases.

A synthesis of peptidylfluoromethanes is described that utilizes the conversion of phthaloyl amino acids into their fluoromethane derivatives. These can be deblocked and elongated. The inactivation of chymotrypsin by Cbz-Phe-CH2F (benzyloxycarbonylphenylalanylfluoromethane) was found to be considerably slower than that of the analogous chloromethane. The fluoromethane analogue inactivates chymo...

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Non-conventional affinity chromatography of serine proteinases and their inhibitors.

From among a wide variety of protein purification techniques affinity chromatography has proved to be particularly effective for separation of proteolytic enzymes and their inhibitors. In this article, following a general description of affinity adsorbents used for purification of proteinases, we overview a simple separation procedure for some serine proteinases and their inhibitors by way of a...

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Aspartic proteinases and their inhibitors.

Proteolytic enzymes are classified on the basis of their catalytic mechanism as belonging to one of four groups: the serine, cysteine, metallo and aspartic proteinases (Kay, 1982). In contrast to the detailed sequence information and three-dimensional structures that have been produced for many enzymes belonging to the first three groups, relatively little is known about the aspartic proteinase...

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ژورنال

عنوان ژورنال: Biochemical Journal

سال: 1986

ISSN: 0264-6021,1470-8728

DOI: 10.1042/bj2390633